Efficacy of trimetazidine and its influence upon metabolic processes in patients with ischemic heart disease

Main Article Content

N. M. Shuba
S. P. Kyrіachenko
T. D. Voronova
O. S. Zalutska
Н. I. Metenkanіch

Abstract

The aim – to examine the effectiveness of the trimetazidine and its metabolic influences in patients with ischemic heart disease.
Material and methods. The pilot study was conducted in 10 patients (6 women and 4 men) aged 49–80 years with stable angina pectoris I–III functional class NYHA. All patients were examined at baseline and after 1 month of therapy with trimetazidine 35 mg twice daily.
Results. After 1 month of therapy with trimetazidine we noted decreased number of angina attacks by 2.39 times and reduce of their duration by 2.32 times. We also observed decrease in index-induced apoptosis, normalization of lipid peroxidation (malondialdehyde reducing and increasing antioxidant status), increase of HDL cholesterol, lower levels of uric acid and C-reactive protein.
Conclusions. These data show clinical efficacy of trimetazidine and its positive effects upon metabolic processes.

Article Details

Keywords:

trimetazidine, ischemic heart disease, apoptosis, lipid peroxidation, C-reactive protein

References

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