Gene polymorphism of folate metabolism in patients with myocardial infarction: results of studying in the Ukrainian population

Main Article Content

Ye. V. Andryeyev
Yu. M. Makukha

Abstract

The aim – to determine the prevalence of gene polymorphism of folate metabolism in patients with myocardial infarction (MI) compared to healthy subjects in Ukraine.
Material and methods. The study involved 51 male, age up to 50 years (mean 43.21±2.8 yrs), who survived myocardial infarction in 2011–2014. The control group consisted of 35 male subjects, having no significant differences
regarding age, smoking and hereditary history.
Results. The study of gene polymorphism revealed heterozygous type MTHFR 677 CT in 29 (56.9 %) patients with MI and 12 (34.3 %) healthy individuals (P<0.05), heterozygote MTHFR 1298 AS – in 25 (49.0 %) patients and 9 (25.7 %) healthy subjects (P<0.05).
Conclusions. Higher prevalence of gene polymorphism of MTHFR, MTR 2756, MTRR 66 among young survivors of myocardial infarction indicates the possible effect of folate metabolism disorders in the pathogenesis of myocardial infarction at a young age. The presence of genetic susceptibility significantly increases the risk of MI in this group of patients.

Article Details

Keywords:

myocardial infarction, gene polymorphism, population

References

Анисенкова А.Ю., Ковалев Ю.Р., Кучинский А.П. и др. Структурные особенности ДНК у женщин с ишемической болезнью сердца // Артериальная гипертензия.– 2008.– № 1.– С. 53–58.

Бушуева О.Ю., Долженкова Е.М., Барышев А.С. и др. Исследование взаимосвязи полиморфизма C667T гена MTHFR c риском развития ишемической болезни сердца у русских жителей Центральной России // Человек и его здоровье: Курский научно-практический вестник.– 2015.– № 4.– С. 76–80.

Antoniades C., Shirodaria C., Leeson P. et al. MTHFR 677 C>T Polymorphism reveals functional importance for 5-methyltetrahydrofolate, not homocysteine, in regulation of vascular redox state and endothelial function in human atherosclerosis // Circulation.– 2009.– Vol. 119 (18).– P. 2507–2715.

Benjamin I., Brown N., Burke G. et al. American Heart Association Cardiovascular Genome-Phenome Study: foundational basis and program // Circulation.– 2015.– Vol. 131 (1).– P. 100–112.

Komarov A.L., Shahmatova O.O., Rebrikov D.V. et al. Pro­­thrombotic polymorphisms and long-term prognosis of patients with stable ischemic heart disease // Rational Pharmacotherapy in Cardiology.– 2011.– Vol. 7 (4).– P. 409–425.

Ma J., Stampfer M.J., Hennekens C.H. et al. Methylene­­tetrahydrofolate reductase polymorphism, plasma folate, homocysteine, and risk of myocardial infarction in US physicians // Circulation.– 1996.– Vol. 94 (10).– P. 2410–2416.

PCR: a practical approach / Ed. M.J. McPherson, P. Quirke, G.R. Taylor.– Oxford: IRL Press, 1991.– 253 p.

Schmitz C., Lindpaintner K., Verhoef P. et al. Genetic polymorphism of methylenetetrahydrofolate reductase and myocardial infarction. A case-control study // Circulation.– 1996.– Vol. 94 (8).– P. 1812–1814.

Schwartz S.M., Siscovick D.S., Malinow M.R. et al. Myocardial infarction in young women in relation to plasma total homo­­cysteine, folate, and a common variant in the methylenetetrahydrofolate reductase gene // Circulation.– 1997.– Vol. 96 (2).– P. 412–417.

Uçar F., Celik S., Yücel B. et al. MTHFR C677T polymorphism and its relationship to myocardial infarction in the Eastern Black Sea region of Turkey // Archives of Medical Research.– 2011.– Vol. 42 (8).– P. 709–712.

Zee R.Y., Mora S., Cheng S. et al. Abstract 3936: Homo­­­cysteine concentration, 5, 10-methylenetetrahydrofolate reductase 677C>T gene polymorphism, and intake of folate and B-vitamins in 24,968 asymptomatic women // Circulation.– 2006.– Vol. 114 (Suppl. 18).– P. 846.

Most read articles by the same author(s)

<< < 23 24 25 26 27 28 29 30 31 32 > >>