The influence of intravascular examination results on the immediate result of stenting of the main trunk of the left coronary artery

Main Article Content

S. M. Furkalo
I. V. Khasyanova
Yu. H. Vahis

Abstract

The purpose of the study is to optimize the immediate results of stenting of the main trunk of the left coronary artery (LCA) in patients with coronary heart disease (CHD) using intravascular imaging methods and modern technological approaches.
Materials and methods. We present the experience of 186 consecutive patients with coronary artery disease in whom stenting of the Left Main (LM) coronary artery was performed.
Results. Patients were divided into 2 groups – group I, «historical» (100 patients), where the intervention was performed without the use of intravascular imaging methods and proximal optimization methods (POT), and group II, which consisted of 86 patients in whom LM stenting was performed using intravascular imaging and modern methods of optimizing the stented segment. In general, groups I and II were comparable. About 20 % of patients had an isolated LM lesion. In other cases, according to the results of coronary angiography, multivessel lesions of the coronary vessels were recorded in the patients. The localization of the lesion was defined as ostial in 7.5 %, stem – 6.9 %, and distal with the involvement of LAD&CX in 85.6 %. Stenting with 1 stent was used in 132 patients (71 % of cases).
Analyzing the final size of the stented LM segment in the groups, we noticed, that in group I, this figure was 3.41±0.41 mm, while in group II it was 3.97±0.61 mm (p<0.0001). 
In 3 patients of group I in 30 day period cardiac death were recorded, in the group II there were 2 (2.3 %) cases of LM dissection treated with additional stent implantation.
In 3 patients (3 %) group I sudden cardiac death was registered in the 30-day period. In group II, there were 2 (2.3 %) cases of ossification, which were resolved by additional stent implantation.
Conclusions. Intravascular imaging to assess the size and results of the intervention, as well as the use of the POT technique, significantly improves the positioning of the stent in the artery and provides a significantly larger diameter of the stented LM. Adequate optimization of the size of the stented LM can be obtained only with the help of intravascular imaging methods.

Article Details

Keywords:

main trunk of the left coronary artery, intravascular ultrasound, percutaneous coronary intervention

References

Furkalo SM. Stenting of the main trunk of the left coronary artery: technical approaches and results of interventions. Cardiac surg intervent cardiol. 2014;1: 20-29. Ukraine.

Stone GW, Kappetein AP, Sabik JF, Pocock SJ, Morice MC, Puskas J, Kandzari DE, Karmpaliotis D, Brown WM 3rd, Lembo NJ, Banning A, Merkely B, Horkay F, Boonstra PW, van Boven AJ, Ungi I, Bogáts G, Mansour S, Noiseux N, Sabaté M, Pomar J, Hickey M, Gershlick A, Buszman PE, Bochenek A, Schampaert E, Pagé P, Modolo R, Gregson J, Simonton CA, Mehran R, Kosmidou I, Généreux P, Crowley A, Dressler O, Serruys PW; EXCEL Trial Investigators. Five-Year Outcomes after PCI or CABG for Left Main Coronary Disease. N Engl J Med. 2019 Nov 7;381(19):1820-30. https://doi.org/10.1056/NEJMoa1909406.

Ahmad Y, Howard JP, Arnold AD, Cook CM, Prasad M, Ali ZA, Parikh MA, Kosmidou I, Francis DP, Moses JW, Leon MB, Kirtane AJ, Stone GW, Karmpaliotis D. Mortality after drug-eluting stents vs. coronary artery bypass grafting for left main coronary artery disease: a meta-analysis of randomized controlled trials. Eur Heart J. 2020 Sep 7;41(34):3228-35. https://doi.org/10.1093/eurheartj/ehaa135.

Sabatine MS, Bergmark BA, Murphy SA, O’Gara PT, Smith PK, Serruys PW, Kappetein AP, Park SJ, Park DW, Christiansen EH, Holm NR, Nielsen PH, Stone GW, Sabik JF, Braunwald E. Percutaneous coronary intervention with drug-eluting stents versus coronary artery bypass grafting in left main coronary artery disease: an individual patient data meta-analysis. Lancet. 2021 Dec 18;398(10318):2247-57. https://doi.org/10.1016/S0140-6736(21)02334-5.

Räber L, Mintz GS, Koskinas KC, Johnson TW, Holm NR, Onuma Y, Radu MD, Joner M, Yu B, Jia H, Meneveau N, de la Torre Hernandez JM, Escaned J, Hill J, Prati F, Colombo A, di Mario C, Regar E, Capodanno D, Wijns W, Byrne RA, Guagliumi G; ESC Scientific Document Group. Clinical use of intracoronary imaging. Part 1: guidance and optimization of coronary interventions. An expert consensus document of the European Association of Percutaneous Cardiovascular Interventions. Eur Heart J. 2018 Sep 14;39(35):3281-300. https://doi.org/10.1093/eurheartj/ehy285.

Ladwiniec A, Walsh SJ, Holm NR, Hanratty CG, Mäkikallio T, Kellerth T, Hildick-Smith D, Mogensen LJH, Hartikainen J, Menown IBA, Erglis A, Eriksen E, Spence MS, Thuesen L, Christiansen EH. Intravascular ultrasound to guide left main stem intervention: a NOBLE trial substudy. EuroIntervention. 2020 Jun 25;16(3):201-9. https://doi.org/10.4244/EIJ-D-19-01003.

Warisawa T, Cook CM, Rajkumar C, Howard JP, Seligman H, Ahmad Y, El Hajj S, Doi S, Nakajima A, Nakayama M, Goto S, Vera-Urquiza R, Sato T, Kikuta Y, Kawase Y, Nishina H, Petraco R, Al-Lamee R, Nijjer S, Sen S, Nakamura S, Lerman A, Matsuo H, Francis DP, Akashi YJ, Escaned J, Davies JE. Safety of Revascularization Deferral of Left Main Stenosis Based on Instantaneous Wave-Free Ratio Evaluation. JACC Cardiovasc Interv. 2020 Jul 27;13(14):1655-64. https://doi.org/10.1016/j.jcin.2020.02.035.

Chen SL, Zhang JJ, Han Y, Kan J, Chen L, Qiu C, Jiang T, Tao L, Zeng H, Li L, Xia Y, Gao C, Santoso T, Paiboon C, Wang Y, Kwan TW, Ye F, Tian N, Liu Z, Lin S, Lu C, Wen S, Hong L, Zhang Q, Sheiban I, Xu Y, Wang L, Rab TS, Li Z, Cheng G, Cui L, Leon MB, Stone GW. Double Kissing Crush Versus Provisional Stenting for Left Main Distal Bifurcation Lesions: DKCRUSH-V Randomized Trial. J Am Coll Cardiol. 2017 Nov 28;70(21):2605-17. https://doi.org/10.1016/j.jacc.2017.09.1066.

Hildick-Smith D, Egred M, Banning A, Brunel P, Ferenc M, Hovasse T, Wlodarczak A, Pan M, Schmitz T, Silvestri M, Erglis A, Kretov E, Lassen JF, Chieffo A, Lefèvre T, Burzotta F, Cockburn J, Darremont O, Stankovic G, Morice MC, Louvard Y. The European bifurcation club Left Main Coronary Stent study: a randomized comparison of stepwise provisional vs. systematic dual stenting strategies (EBC MAIN). Eur Heart J. 2021 Oct 1;42(37):3829-39. https://doi.org/10.1093/eurheartj/ehab283.

Tarantini G, Fovino LN, Varbella F, Trabattoni D, Caramanno G, Trani C, De Cesare N, Esposito G, Montorfano M, Musto C, Picchi A, Sheiban I, Gasparetto V, Ribichini FL, Cardaioli F, Saccà S, Cerrato E, Napodano M, Martinato M, Azzolina D, Andò G, Mugnolo A, Caruso M, Rossini R, Passamonti E, Teles RC, Rigattieri S, Gregori D, Tamburino C, Burzotta F. A large, prospective, multicentre study of left main PCI using a latest-generation zotarolimus-eluting stent: the ROLEX study. EuroIntervention. 2023 Feb 6;18(13):e1108-e1119. https://doi.org/10.4244/EIJ-D-22-00454.

Dérimay F, Rioufol G, Cellier G, Souteyrand G, Finet G. Benefits of final proximal optimization technique (POT) in provisional stenting. Int J Cardiol. 2019 Jan 1;274:71-3. https://doi.org/10.1016/j.ijcard.2018.09.041.