Diabetes and atherosclerosis: epigenetic mechanisms of pathogenesis. A review
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Abstract
The review summarizes and analyzes epigenetic changes accompanying cardiovascular complications in diabetes. Data on the participation of epigenetic modifications in pathological changes of endothelial cells, smooth muscle cells and macrophages leading to atherosclerosis are presented. The role of various miRNAs in the differentiation, activation, inflammation, proliferation and migration of vascular cells is described. It has been shown that histone modifications, DNA methylation and miRNA spectrum change participate in the initiation and development of cardiovascular diseases in diabetes, and their study and application of the acquired data has great diagnostic, prognostic, and therapeutic potential.
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