Malignant ventricular arrhythmias in patient with cardiac angiosarcoma

Main Article Content

Yu. V. Zinchenko
O. І. Frolov
V. A. Krichkevych
Ye. V. Mоgilnitsky
A. Yu. Rybak
О. M. Rozhkova 
R. D. Shevelyov 


Malignant tumors of the heart are very rare in clinical practice. The causes of the disease so far have not been established. Therefore, a rare clinical case of in vivo diagnosis of primary cardiac tumor (angiosarcoma, complicated by ventricular tachycardia refractory to antiarrhythmic treatment) is of a clinical interest.
Key words: heart tumors, angiosarcoma, ventricula

Article Details


heart tumors, angiosarcoma, ventricular tachycardia


Пальцев М.А., Аничков Н.М. Патологическая анатомия.– Т. 2 (Ч. 1). – М.: Медицина, 2001. – 736 с.

Клатт Э.К. Атлас патологии Роббинса и Котрана. Пер. с англ. О.Д. Мишнёва, А.И. Щёголева.– М.: Логосфера, 2010.– 544 с.

Краевский Н.А., Смольянников А.В., Саркисов Д.С. Патологоанатомическая диагностика опухолей человека. Т. 2.– 4-е изд., перераб. и доп.– М.: Медицина, 1993.– 688 с.

Antonuzzo L., Rotella V., Mazzoni F. et al. Primary cardiac angiosarcoma: a fatal disease // Case Rep. Med.– 2009.–

Vol. 2009.– P. 591–612. doi: 10.1155/2009/591512.

Barreiro M., Renilla A., Jimenez J.M. et al. Primary cardiac tumors: 32 years of experience from a Spanish tertiary surgical center // Cardiovasc. Pathol.– 2013.– Vol. 22 (6).– Р. 424–427.

Cardoso M.E., Canale L.S., Ramos R.G. et al. Cardiac Angiosarcoma // Case Rep. Cardiol.– 2011.– Vol. 2011.– P. 340–681. doi: 10.1155/2011/340681.

Blackmon S.H., Patel A.R., Bruckner B.A. et al. Cardiac autotransplantation for malignant or complex primary left-heart tumors // Tex Heart Inst. J.– 2008.– Vol. 35 (3).– P. 296–300.

Burke A.P., Cowan D., Virmani R. Primary sarcomas of the heart // Cancer.– 1992.– Vol. 69 (2).– P. 387–395.

Dein J.R., Frist W.H., Stinson E.B. et al. Primary cardiac neoplasms. Early and late results of surgical treatment in 42 patients // J. Thorac. Cardiovasc. Surg.– 1987.– Vol. 93 (4).– P. 502–511.

Fernandes F., Soufen H.N., Ianni B.M. Primary neoplasms of the heart. Clinical and histological presentation of 50 cases // Arq. Bras. Cardiol.– 2001.– Vol. 76 (3).– Р. 231–217.

Furukawa N., Gummert J., Börgermann J. Complete resection of undifferentiated cardiac sarcoma and reconstruction of the atria and the superior vena cava: case report // J. Cardiothorac. Surg.– 2012.– Vol. 27.– Р. 7–96.

Fussen S., De Boeck B.W., Zellweger M.J. et al. Cardio­­­vascular magnetic resonance imaging for diagnosis and clinical management of suspected cardiac masses and tumours // Eur. Heart J.– 2011.– Vol. 32 (12).– Р. 1551–1560.

Gowdamarajan A., Michler R.E. Therapy for primary cardiac tumors: is there a role for heart transplantation? // Curr. Opin. Cardiol.– 2000.– Vol. 15 (2).– Р. 121–125.

Grandmougin D., Fayad G., Decoene C. Total orthotopic heart transplantation for primary cardiac rhabdomyosarcoma: factors influencing long-term survival // Ann. Thorac. Surg.– 2001.– Vol. 71 (5).– Р. 1438–1441.

Herrmann M.A., Shankerman R.A., Edwards W.D. et al. Primary cardiac angiosarcoma: a clinicopathologic study of six cases // J. Thoracic. Cardiovasc. Surgery.– 1992.– Vol. 103 (4).– Р. 655–664.

Hoffmeier A., Deiters S., Schmidt C. Radical resection of cardiac sarcoma // Thorac. Cardiovasc. Surg.– 2004.– Vol. 52 (2).– Р. 77–81.

Hoffmeier A., Scheld H.H., Tjan T.D. Ex situ resection of primary cardiac tumors // Thorac. Cardiovasc. Surg.– 2003.– Vol. 51 (2).– Р. 99–101.

Jimenez Mazuecos J.M., Fuentes Manso R., Segovia Cubero J. et al. Is heart transplantation for primary cardiac sarcoma a useful therapeutic option? // Rev. Esp. Cardiol.– 2003.– Vol. 56 (4).– Р. 408–411.

Kosuga T., Fukunaga S., Kawara T. Surgery for primary cardiac tumors. Clinical experience and surgical results in 60 patients // J. Cardiovasc. Surg. (Torino).– 2002.– Vol. 43 (5).– Р. 581–587.

Look Hong N.J., Pandalai P.K., Hornick J.L. et al. Cardiac angiosarcoma management and outcomes: 20-year single-institution experience // Ann. Surg. Oncol.– 2012.– Vol. 19 (8).– Р. 2707–2715.

Meng Q., Lai H., Lima J. Echocardiographic and pathologic characteristics of primary cardiac tumors: a study of 149 cases // Int. J. Cardiol. 2002.– Vol. 84 (1).– Р. 69–75.

Neragi-Miandoab S., Kim J., Vlahakes G.J. Malignant

tu­­­­mours of the heart: a review of tumour type, diagnosis and therapy // Clin. Oncol. (R. Coll. Radiol.).– 2007.– Vol. 19 (10).– Р. 748–756.

Patel S.D., Peterson A., Bartczak A. et al. Primary cardiac angiosarcoma – a review // Med Sci Monit.– 2014.– Vol. 20.– Р. 103–109. doi: 10.12659/MSM.889875.

Piazza N., Chughtai T., Toledano K. Primary cardiac tumours: eighteen years of surgical experience on 21 patients // Can. J. Cardiol.– 2004.– Vol. 20 (14).– Р. 1443–1448.

Randhawa K., Ganeshan A., Hoey E.T. Magnetic resonance imaging of cardiac tumors: part 1, sequences, protocols, and benign tumors // Curr. Probl. Diagn Radiol.– 2011.– Vol. 40 (4).– Р. 158–168.

Raaf H.N., Raaf J.H. Sarcomas related to the heart and vasculature // Semin Surg Oncol.– 1994.– Vol. 10 (5).– Р. 374–382.

Raaf H.N., Raaf J.H. Sarcomas of the heart and great vessels: vascular replacement // Soft Tissue Sarcomas: Diagnosis and Treatment / Ed. J.H. Raaf.– St. Louis, Mo: Mosby. Year Book Medical Pub, 1993.– P. 123–138.

Randhawa K., Ganeshan A., Hoey E.T. Magnetic resonance imaging of cardiac tumors: part 2, malignant tumors and tumor-like conditions // Curr. Probl. Diagn. Radiol.– 2011.– Vol. 40 (4).– Р. 169–179.

Reardon M.J., Walkes J.C., Benjamin R. Therapy insight: malignant primary cardiac tumors // Nat. Clin. Pract. Cardiovasc. Med.– 2006.– Vol. 3 (10).– Р. 548–553.

Sarjeant J.M., Butany J., Cusimano R.J. Cancer of the heart: epidemiology and management of primary tumors and metastases // Am. J. Cardiovasc. Drugs. 2003.– Vol. 3 (6).– Р. 407–421.

Shanmugam G. Primary cardiac sarcoma // Eur. J. Cardio­­­thorac. Surg.– 2006.– Vol. 29 (6).– Р. 925–932.

Simpson L., Kumar S.K., Okuno S.H. et al. Malignant primary cardiac tumors: review of a single institution experience // Cancer.– 2008.– Vol. 112 (11).– Р. 2440–2446.

Stoica S.C., Mitchell I.M., Foreman J. Atrial transplantation for recurrent cardiac sarcoma // J. Heart Lung Transplant.– 2001.– Vol. 20 (11).– Р. 1220–1223.

Uberfuhr P., Meiser B., Fuchs A. Heart transplantation: an approach to treating primary cardiac sarcoma? // J. Heart Lung Transplant.– 2002.– Vol. 21 (10).– Р. 1135–1139.

Vandersalm T.J. Unusual primary tumors of the heart // Semin. Thorac. Cardiovasc. Surg.– 2000.– Vol. 12 (2).– Р. 89–100.

Yuan S.M., Shinfeld A., Lavee J. et al. Imaging morphology of cardiac tumours // Cardiol. J.– 2009.– Vol. 16 (1).– Р. 26–35.

Zhang P.J., Brooks J.S., Goldblum J.R. et al. Primary cardiac sarcomas: a clinicopathologic analysis of a series with follow-up information in 17 patients and emphasis on long-term survival // Hum. Pathol.– 2008.– Vol. 39 (9).– Р. 1385–1395.