NT-proBNP level and lesion of the right ventricle in patients with pulmonary embolism

Main Article Content

V. I. Tseluyko
L. M. Yakovleva
S. M. Sukhova
O. V. Radchenko
T. V. Pylova
A. S. Vnukova
K. Yu. Kinoshenko
M. I. Karavaitseva


The aim – to study the relationship between the level of NT-proBNP, clinical-anamnestic and echocardiographic parameters in patients with pulmonary embolism (PE).
Materials and methods. The study was carried out on 45 patients with PE, which was confirmed by computed tomo­­graphy. An echocardiographic study was carried out during hospitalization of patients according to the standard protocol. The examination plan of patients, along with standard laboratory tests, included the determination of the level of highly sensitive troponin I, C-reactive peptide (CRP) and NT-proBNP.
Results and discussion. The level of NT-proBNP is increased in patients with PE, even in the absence of heart failure (2932±266 pg/ml). There were no significant differences in the level of the indicator depending on the gender of patients (p=0.3), on the presence of arterial hypertension (p=0.92) and the concomitant oncological process (p=0.88). A correlation was found between NT-proBNP level and the size of the right and left atrium: right atrium (p=0.014), left atrium (p=0.025). The relationship between the level of NT-proBNP and the pressure in the pulmonary artery according to ultrasound data was proved (in patients with PE without signs of pulmonary hypertension, the level of NT-proBNP is
405 pg/ml, versus 4067 pg/ml in the group of patients with increased pressure in the pulmonary artery (p=0.0047). A correlation was found between the levels of NT-proBNP and CRP.
Conclusions. There is a significant increase in the level of NT-proBNP in patients with PE, the degree of which correlates with an increase in the size of the right atrium and pressure in the pulmonary artery (p=0.0047).

Article Details


pulmonary embolism, venous thromboembolism, short-term prognosis, natriuretic peptide


Клименко А.А., Шостак Н.А., Демидова Н.А., Новиков И.В. Хроническая постэмболическая легочная гипертензия: новые аспекты формирования и прогрессирования заболевания // Клиницист.– 2011.– № 5 (1).– C. 14–17.doi: https://doi.org/10.17650/1818-8338-2011-1-14-17.

Целуйко В.Й., Сухова С.М., Кіношенко К.Ю. Можливості 2D-спекл-трекінг ехокардіографії щодо діагностики дисфункції правого шлуночка у хворих з гострою тромбоемболією легеневої артерії // Укр. кардіол. журн. – 2017.– № 1.– С. 70–75.

Arshad N., Isaksen T., Hansen J., Brækkan S. Time trends in incidence rates of venous thromboembolism in a large cohort recruited from the general population // Eur. J. Epidemiology.– 2017.– Vol. 32 (4).– P. 299–305. doi: https://doi.org/10.1007/s10654-017-0238.

Benjamin E., Muntner P., Alonso A. et al. Heart Disease and Stroke Statistics - 2019 Update: A Report From the American Heart Association // Circulation.– 2019.– Vol. 139 (10).doi: https://doi.org/10.1161/cir.0000000000000659.

Bikdeli B., Lobo J., Jiménez D. et al. Early Use of Echocardiography in Patients With Acute Pulmonary Embolism: Findings From the RIETE Registry // J. Amer. Heart Association.– 2018.– Vol. 7 (17). doi: https://doi.org/10.1161/jaha.118.009042.

Bondarsky E., Schaikewitz M., Filopei J., Steiger D. Brain natriuretic peptide/troponin I ratio in pulmonary embolism // Chest.– 2017.– Vol. 152, Issue 4. doi: https://doi.org/10.1016/j.chest.2017.08.1073.

Borz-Baba C., Munir M., Wakefield D., Feinn R. Brain natriuretic peptide and troponin T in patients with acute pulmonary embolism and grade 3 obesity: a retrospective analysis // Cureus.– 2020.– Vol. 12 (7).– P. e9265. doi: https://doi.org/10.7759/cureus.9265.

Cavallazzi R., Nair A., Vasu T., Marik P.E. Natriuretic peptides in acute pulmonary embolism: a systematic review // Intensive Care Med.– 2008.– Vol. 34 (12).– P. 2147–2156. doi: https://doi.org/10.1007/s00134-008-1214-5.

Doresa H., Fonsecaa C., Leala S. NT-proBNP for risk stratification of pulmonary embolism NT-proBNP na estratificação de risco no tromboembolismo pulmonary // Centro Hospitalar de Lisboa Ocidental, Lisboa. Portugal 7.

El-Habashya M.M., Khamisa A.A., Abdelhadyb A.M. Prognostic value of brain natriuretic peptide in acute pulmonary embolism // Egypt. J. Chest Diseases and Tubercu­­­losis.– 2014.– Vol. 63, Issue 4.– P. 1035–1038.

Fitzgerald S. Pulmonary embolism prevalent among patients hospitalized for syncope // Neurology Today.– 2016.– Vol. 16 (22).– P. 34–35. doi: https://doi.org/10.1097/01.nt.0000510776.35882.ef.

Gall H., Hoeper M., Richter M. et al. An epidemiological analysis of the burden of chronic thromboembolic pulmonary hypertension in the USA, Europe and Japan // Eur. Respiratory Review.– 2017.– Vol. 26 (143).– P. 160121.doi: https://doi.org/10.1183/16000617.0121.

Goldhaber S., Visani L., De Rosa M. Acute pulmonary embolism: clinical outcomes in the International Cooperative Pulmonary Embolism Registry (ICOPER) // Lancet.– 1999.– Vol. 353 (9162).– P. 1386–1389. doi: https://doi.org/10.1016/s0140-6736(98)07534-5.

Heit J. The Epidemiology of Venous Thromboembolism in the Community // Arteriosclerosis, Thrombosis, And Vascular Biology.– 2008.– 28(3).– P. 370–372. doi: https://doi.org/10.1161/atvbaha.108.162545.

Jiménez D., Bikdeli B., Barrios D. et al. Epidemiology, patterns of care and mortality for patients with hemodynamically unstable acute symptomatic pulmonary embolism // Intern. J. Cardiology.– 2018.– Vol. 269.– P. 327–333. doi: https://doi.org/10.1016/j.ijcard.2018.07.059.

Kempny A., McCabe C., Dimopoulos K. et al. Incidence, mortality and bleeding rates associated with pulmonary embolism in England between 1997 and 2015 // Intern. J. Cardiology.– 2019.– Vol. 277.– P. 229–234. doi: https://doi.org/10.1016/j.ijcard.2018.10.001.

Kiely D.G., Kennedy N.S., Pirzada O. et al. Elevated levels of natriuretic peptides in patients with pulmonary thromboembolism // Respiratory Medicine.– 2005.– Vol. 99, Issue 10.– P. 1286–1291. doi: https://doi.org/10.1016/j.rmed.2005.02.029.

Kiran G., Chandrasekhar P., Ali S. Association between 2D echocardiographic right atrial volume to left atrial volume (RAV/LAV) ratio and in-hospital prognosis in thrombolysed acute pulmonary thromboembolism patients // Indian Heart J.– 2020.– Vol. 72 (6).– P. 610–613. doi: https://doi.org/10.1016/j.ihj.2020.09.008.

Konstantinides S., Meyer G., Becattini C. et al. 2019 ESC Guidelines for the diagnosis and management of acute pulmonary embolism developed in collaboration with the European Respiratory Society (ERS) // Eur. Heart J.– 2019.– Vol. 41(4).– P. 543–603. doi: https://doi.org/10.1093/eurheartj/ehz405.

Konstantinides S.V., Meyer G., Becattini C. et al. 2019 ESC Guidelines for the Diagnosis and Management of Acute Pulmonary Embolism Developed in Collaboration With the European Respiratory Society (ERS): The Task Force for the Diagnosis and Management of Acute Pulmonary Embolism of the European Society of Cardiology (ESC) // Eur. Heart J.– 2020.– Vol. 41 (4).– P. 543–603. doi: https://doi.org/10.1093/eurheartj/ehz405.

Olié V., Fuhrman C., Chin F. et al. Time trends in pulmonary embolism mortality in France, 2000-2010 // Thrombosis Research.– 2015.– Vol. 135(2).– P. 334–338. doi: https://doi.org/10.1016/j.thromres.2014.12.002.

Schreiber D., Fansler J., Briese B. et al. Risk Stratification of Patients with Acute Pulmonary Embolism using the Pulmonary Embolism Severity Index Score from the Emergency Medicine Pulmonary Embolism in the Real World Registry (EMPEROR) // J. Emergency Medicine.– 2009.– Vol. 37 (2).– P. 218. doi: https://doi.org/10.1016/j.jemermed.2009.06.023.

Spirk D., Aujesky D., Stuck A. et al. Clinical Outcomes of Venous Thromboembolism in Patients with and without Cancer: The SWIss Venous ThromboEmbolism Registry (SWIVTER) // Seminars In Thrombosis And Hemostasis.– 2016.– Vol. 42 (06).– P. 642–649. doi: https://doi.org/10.1055/s-0036-1584131.

Spirk D., Sebastian T., Banyai M. et al. Venous Thromboembolism and Renal Impairment: Insights from the SWIss Venous ThromboEmbolism Registry (SWIVTER) // Seminars In Thrombosis And Hemostasis.– 2019.– Vol. 45 (08).– P. 851–858. doi: https://doi.org/10.1055/s-0039-1698770.

Most read articles by the same author(s)

1 2 > >>