QT prolongation as a significant cardiovascular complication in cancer therapy

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S. M. Kozhukhov
S. I. Deyak
O. Ye. Bazyka
N. V. Dovganich
O. Ya. Yarynkina
N. V. Tkhor


The widespread introduction of new anticancer drugs and treatment technologies has contributed to an increase in the survival rate of cancer patients. At the same time, the development of cardiovascular complications in the setting of anticancer treatment often leads to a decrease in the quality of life and worse prognosis.
One of the manifestations of cardiovascular complications during cancer treatment is QT prolongation with various cardiac arrhythmias.
The article is based on the analysis of randomized clinical trials and meta-analyses, and the recommendations of the European Society of Cardiology on Cardio-Oncology. The review describes the risk factors and classification of QT prolongation caused by anticancer therapy.The main groups of anticancer drugs that induce changes in the QT interval are analyzed. The methods and frequency of examination of cancer patients with various pathological conditions and comorbidities that can lead to QT prolongation during and after cancer treatment are considered.
The review is devoted to the analysis of changes in the QT interval and clinical application of decision-making algorithms to minimize cardiotoxicity in order to improve the effectiveness of anticancer treatment.


cardiotoxicity, QT interval, QT prolongation, risk factors, chemotherapy, rhythm disturbances


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