Cardioprotection in patients with ischemic heart disease evaluated by digital processing of electro­­cardiogram

Main Article Content

V. K. Tashchuk
O. S. Polianska
P. R. Ivanchuk
T. M. Amelina
M. V. Tashchuk

Abstract

The aim – to evaluate the cardioprotective effect of metabolic therapy in patients with coronary heart disease (ICD) by digital processing of a standard electrocardiogram using original software.
Material and methods. 46 patients with stable angina pectoris of II functional class were examined. In order to determine the cardioprotective effect of metabolic therapy, the results of digital processing of the standard ECG in patients with coronary heart disease were analyzed using original software. with the evaluation of the effect of drugs (tivortin, tivorel, tiotriazoline, corvitine) with antiarrhythmic anticipation, in comparison with the effects of amiodarone and bisoprolol on the main parameters of HRD and dispersion of the QT interval, the angle of inclination of the ST segment and the results of the analysis differentiated T wave. The possibility of an effective quantitative evaluation of the electrocardiogram with its digital processing (digitalization) with the use of its own Smart-ECG software in patients with stable angina pectoris was proven.
Results. In the complex analysis of effects from the use of drugs, it was found that tivortin/tivorel reduced the risk of adverse events with stable angina pectoris and activated parasympathetic contour, corvitine and tiotriazoline – reduced the dispersion of the QT interval, tiotriazoline, corvitine and tivortin, accelerated transient depression of the ST segment  – reducing the risk of coronary heart disease and increasing antiarrhythmic effect. Bisoprolol and amiodarone increase the SDNN score and consequently reduce the risk of adverse events with stable angina pectoris, amiodarone stimulates the activation of the parasympathetic contour and less efficiently affects ST slope than bisoprolol, both drugs slightly optimize the ratio of maximum velocities and thus maintain anti-ischemic status.
Conclusions. Quantitative evaluation of the electrocardiogram with its digital processing (digitization) can be recommended for increasing the effectiveness of the individual approach in the treatment of patients with acute and chronic ischemic heart disease with the objectification of cardioprotection.

Article Details

Keywords:

Quantitative evaluation of electrocardiogram, cardioprotection, stable angina pectoris, beta-blockers, amiodarone., Quantitative evaluation of electrocardiogram, cardioprotection, stable angina pectoris, beta-blockers, amiodarone.

References

Nakaz MOZ Ukrainy vid 02.03.2016 № 152 «Pro zatverdzhennia ta vprovadzhennia medyko-tekhnolohichnykh dokumentiv zi standartyzatsii medychnoi dopomohy pry stabilnii ishemichnii khvorobi sertsia», Unifikovanyi klinichnyi protokol pervynnoi, vtorynnoi (spetsializovanoi) ta tretynnoi (vysokospetsializovanoi) medychnoi dopomohy «Stabilna ishemichna khvoroba sertsia». – Rezhym dostupu: http://mtd.dec.gov.ua/index.php/uk/reiestr-mtd/item/62-stabilna-ishemichna-khvoroba-sertsia] (in Ukr.).

Svishchenko YeP, Solobiukova NA, Makarov AA. Metaanaliz efektyvnosti ta bezpeky zastosuvannia likarskoho zasobu Tiotryazolin® pry stabilnykh formakh ishemichnoi khvoroby sertsia. Zdorovia Ukrainy [Health of Ukraine]. 2016. – dostup za posylanniam http://health-ua.com/article/4913-metaanaliz-effektivnosti-i-bezopasnosti-primeneniya-tiotriazolina-pri-stabi (in Ukr.).

Tashchuk VK, Ivanchuk PR, Polianska OS, Tashchuk IA, Al-Salama MV. Doslidzhennia variabelnosti sertsevoho rytmu za vlasnoho matematychnoho zabezpechennia – mozhlyvosti i perspektyvy. Buk. med. Visnyk [Bukovinsky medical bulletin]. 2015;19(3):182–187. (in Ukr.). https://is.gd/2DbMYs

Tashchuk VK, Polianska OS, Ivanchuk PR, Kostenko OV, Zlonikova KM. Stvorennia prohramnoho zabezpechennia dlia kilkisnoi otsinky zmin sehmenta ST pry elektrokardiohrafii. Klin. ta eksperym. Patol [Clinical and Experimental Pathology]. 2015;14(1):155–159. (in Ukr.). https://is.gd/2DbMYs

Baumert M, Porta A, Vos MA, Malik M, Couderc JP, Laguna P, Piccirillo G, Smith GL, Tereshchenko LG, Volders PG. QT interval variability in body surface ECG: measurement, physiological basis, and clinical value: position statement and consensus guidance endorsed by the European Heart Rhythm Association jointly with the ESC Working Group on Cardiac Cellular Electrophysiology. EP Europace.2016;18(6):925–944. http://doi.org/10.1093/europace/euv405

Hasan MA, Abbott D, Baumert M, Krishnan S. Increased beat-to-beat T-wave variability in myocardial infarction patients. Biomed. Tech. (Berl). 2016. Режим доступу: /j/bmte.ahead-of-print/bmt-2015-0186/bmt-2015-0186.xml. doi: http://doi.org/10.1515/bmt-2015-0186.

Heldeweg ML, Liu N, Koh ZX, Fook-Chong S, Lye WK, Harms M, Ong ME. A novel cardiovascular risk stratification model incorporating ECG and heart rate variability for patients presenting to the emergency department with chest pain. Crit Care. 2016 Jun 11;20(1):179. doi: http://doi.org/10.1186/s13054-016-1367-5.

Hisamatsu T1, Ohkubo T, Miura K, Yamamoto T, Fujiyoshi A, Miyagawa N, Kadota A, Takashima N, Nagasawa SY, Kita Y, Murakami Y, Okayama A, Horie M, Okamura T, Ueshima H; NIPPON DATA90 Research Group. Association between J-point elevation and death from coronary artery disease--15-year follow up of the NIPPON DATA90. Circ. J.2013;77(5):1260-1266 https://www.ncbi.nlm.nih.gov/pubmed/23358431.

Ibanez B, James S, Agewall S, Antunes MJ, Bucciarelli-Ducci C, Bueno H, Caforio ALP, Crea F, Goudevenos JA, Halvorsen S, Hindricks G, Kastrati A, Lenzen MJ, Prescott E, Roffi M, Valgimigli M, Varenhorst C, Vranckx P, Widimský P; ESC Scientific Document Group. 2017 ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation: The Task Force for the management of acute myocardial infarction in patients presenting with ST-segment elevation of the European Society of Cardiology (ESC). Eur. Heart. J.2018;39(2):119–177. http://doi.org/10.1093/eurheartj/ehx393.

Most read articles by the same author(s)

<< < 8 9 10 11 12 13 14 15 16 17 > >>