Predictors of 24-month survival in patients with chronic heart failure and reduced left ventricular ejection fraction depending on gender

Main Article Content

L. G. Voronkov
O. L. Filatova
A. V. Liashenko
N. A. Tkach
N. G. Lipkan

Abstract

The aim – to compare survival rates and predictors of the onset of lethal outcome in men and women with chronic heart failure (CHF) with reduced left ventricular ejection fraction (LVEF) during 24-months follow-up.
Material and methods. 356 patients with ischemic CHF (NYHA II–ІV) and LVEF < 40 % were examined. Cumulative survival was calculated by Kaplan – Meier method. Comparison of survival in groups was performed by Mantel – Cox test. Predictors of survival were determined by multiple logistic regression. Cut-off values of clinical variables associated with non – survival during 24 months of follow-up were determined.
Results. Analysis of survival in patients with CHF and reduced LVEF showed that cumulative survival at the end of 24 manth of follow-up was not significantly different (P=0.092), 68 % in men and 72 % in women. Factors associated with poor prognosis varied significantly depending on gender. We determined indicators associated with poor survival by cluster analysis. In men these were: left ventricle free wall thickness < 0,75 сm, ureic acid > 627 mkmol/L, LVESV
index > 110 cm/m2, LVEF < 25 %, LVEDV > 340 mL (ОR 6.8–5.7). In women, these were glucose level > 11,4 l/L, LVESV > 287 mL, LVEDV > 302 mL, LVESD > 6,5 cm, IVS thickness less than 0,7 cm, LVEDV index > 176 cm/m2
(ОR 16.2–11.2).
Conclusion. Survival of men and women with CHF and reduced LVEF during 24-month of follow-up not significantly different, while predictors of lethal outcome are different.

Article Details

Keywords:

heart failure, survival, predictors, gender

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